干燥综合征患者唇腺中环氧化酶-1（COX-1）的表达
Expression of cyclooxygenase-1 (COX-1) in labial salivary glands of Sjögren's syndrome.
作者信息
Tominaga M, Migita K, Sano H, Fukui W, Kohno M, Tsubouchi Y, Honda S, Fukuda T, Nakamura H, Yamasaki S, Kawabe Y, Kawakami A, Eguchi K
机构信息
First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
出版信息
Clin Exp Immunol. 2000 Dec;122(3):459-63. doi: 10.1046/j.1365-2249.2000.01302.x.
COX plays an important role in inflammatory diseases such as rheumatoid arthritis. To determine the role of COX in Sjögren's syndrome (SS), we examined COX expression in the salivary glands of SS patients. We examined 15 patients with SS and two normal subjects. Labial salivary gland tissue samples were analysed immunohistochemically using anti-COX-1 and COX-2 antibodies. All biopsy samples from 15 patients with SS were stained for COX-1. In contrast, COX-1 immunostaining was not detected in normal salivary gland tissues. Co-expression of COX-1 and CD68 was confirmed by mirror section technique and double antibody immunostaining. This finding indicated that COX-1-expressing cells in SS salivary glands were infiltrating macrophages. In contrast to COX-1 staining, only a little COX-2 immunostaining was observed in salivary gland tissues from SS patients. These data suggest that COX-1 expression on infiltrating macrophages may contribute to the inflammatory process of salivary glands in SS.
COX在类风湿性关节炎等炎症性疾病中发挥着重要作用。为了确定COX在干燥综合征（SS）中的作用，我们检测了SS患者唾液腺中COX的表达。我们研究了15例SS患者和2名正常受试者。使用抗COX-1和COX-2抗体对唇唾液腺组织样本进行免疫组织化学分析。15例SS患者的所有活检样本均检测到COX-1染色。相比之下，正常唾液腺组织中未检测到COX-1免疫染色。通过镜像切片技术和双抗体免疫染色证实了COX-1和CD68的共表达。这一发现表明，SS唾液腺中表达COX-1的细胞是浸润性巨噬细胞。与COX-1染色不同，在SS患者的唾液腺组织中仅观察到少量COX-2免疫染色。这些数据表明，浸润性巨噬细胞上的COX-1表达可能有助于SS中唾液腺的炎症过程。
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