Tishler M, Yaron I, Raz A, Meyer F A, Yaron M
Department of Rheumatology, Ichilov Hospital, Tel Aviv-Sourasky Medical Centre, Israel.
Ann Rheum Dis. 1996 Mar;55(3):202-4. doi: 10.1136/ard.55.3.202.
To investigate eicosanoid concentrations in the saliva of patients with primary Sjögren's syndrome (SS).
Whole mixed saliva of 36 subjects was assayed for eicosanoid concentrations using a radioimmunoassay. Patients with primary SS having positive lip biopsy served as the study group; their results were compared with data from patients with dry mouth and negative lip biopsy (dry mouth group), and with a group of normal healthy controls.
Concentrations of thromboxane B2 were significantly (p < 0.01) increased in 18 patients with primary SS compared with 10 patients with dry mouth and eight healthy normal controls (1.95 (SD 0.51) ng/ml saliva compared with 0.52 (0.1) ng/ml and 0.3 (0.1) ng/ml, respectively). Similarly, prostaglandin E2 concentrations were also significantly increased (p < 0.01) in 11 patients with primary SS compared with five patients with dry mouth and eight normal controls (3.75 (0.82) ng/ml saliva compared with 0.32 (0.1) ng/ml and 0.41 (0.1) ng/ml, respectively).
Salivary concentrations of eicosanoids are significantly increased in patients with primary SS, and this may prove helpful in the diagnosis of this disease.
研究原发性干燥综合征（SS）患者唾液中类花生酸的浓度。
采用放射免疫分析法检测36名受试者的全混合唾液中类花生酸的浓度。唇活检阳性的原发性SS患者作为研究组；将他们的结果与口干且唇活检阴性的患者（口干组）以及一组正常健康对照的数据进行比较。
与10名口干患者和8名健康正常对照相比，18名原发性SS患者的血栓素B2浓度显著升高（p < 0.01）（唾液中分别为1.95（标准差0.51）ng/ml，而口干患者为0.52（0.1）ng/ml，健康对照为0.3（0.1）ng/ml）。同样，与5名口干患者和8名正常对照相比，11名原发性SS患者的前列腺素E2浓度也显著升高（p < 0.01）（唾液中分别为3.75（0.82）ng/ml，而口干患者为0.32（0.1）ng/ml，健康对照为0.41（0.1）ng/ml）。
原发性SS患者唾液中类花生酸的浓度显著升高，这可能有助于该病的诊断。
