某些咪唑烷 -2- 酮衍生物的局部麻醉和抗心律失常作用。
Local anesthetic and antiarrhythmic effect of some imidazolidin-2-one derivatives.
作者信息
Librowski T, Filipek B, Czarnecki R
机构信息
Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
出版信息
Acta Pol Pharm. 2000 Sep-Oct;57(5):391-6.
PMID:11126032
Abstract
A series of the new derivatives of imidazolidin-2-one was investigated in order to determine their local anesthetic and antiarrhythmic activity. All compounds tested showed strong local anesthetic properties and variable effects on adrenaline-, aconitine- and barium chloride- induced arrhythmia. The results suggest that the antiarrhythmic properties of these compounds is related to their local anesthetic properties.
摘要
为了确定其局部麻醉和抗心律失常活性，对一系列咪唑烷 - 2 - 酮的新衍生物进行了研究。所有测试的化合物均显示出较强的局部麻醉特性，并且对肾上腺素、乌头碱和氯化钡诱导的心律失常有不同的影响。结果表明，这些化合物的抗心律失常特性与其局部麻醉特性有关。
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