具有天然单萜结构的1,2 - 氨基醚的合成及某些药理性质
Synthesis and some pharmacological properties of 1,2-amino ethers with natural monoterpene structures.
作者信息
Siemieniuk A, Szałkowska-Pagowska H, Lochyński S, Piatkowski K, Filipek B, Krupińska J, Czarnecki R, Librowski T, Szymańska I
机构信息
Institute of Organic and Physical Chemistry, Polytechnical University, Wrocław, Poland.
出版信息
Pol J Pharmacol Pharm. 1992 Mar-Apr;44(2):187-200.
Synthesis and physicochemical and pharmacological properties of 10 analogs of 2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy]N, N-diethylamino ethane (3) have been described. The compounds possess toxicity close to or lower than the parent compound--myrtecaine, have no antiarrhythmic activity but some of them (15, 16, 22, 24), similarly as compound 3, show quite strong local anesthetic action.
已描述了2-[2-(6,6-二甲基双环[3.1.1]庚-2-烯-2-基)乙氧基]N,N-二乙氨基乙烷(3)的10种类似物的合成、物理化学性质及药理性质。这些化合物的毒性接近或低于母体化合物——桃金娘卡因，无抗心律失常活性，但其中一些化合物(15、16、22、24)与化合物3类似，显示出相当强的局部麻醉作用。
Zotero 插件