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纳洛酮可拮抗茶碱诱导的吗啡对大鼠伤害性反应抑制作用的增强。

Naloxone antagonizes theophylline-induced potentiation of morphine inhibition of a nociceptive reaction in rats.

作者信息

Paalzow G

出版信息

Psychopharmacology (Berl). 1979 Apr 25;62(3):235-9. doi: 10.1007/BF00431953.

DOI:10.1007/BF00431953
PMID:111289
Abstract

In the rat, theophylline has been shown to potentiate the effect of morphine on the threshold for vocalisation after withdrawal of stimulation. This response to painful stimulation is considered to be integrated at the level of the thalamus-hypothalamus-rhinencephalon. Naloxone antagonized the effect of the combined treatment with morphine and theophylline, suggesting pharmacological specificity for morphine. Moreover, the theophylline-induced enhancement of this pharmacological response to morphine was attenuated after pimozide pretreatment, indicating an underlying dopaminergic mechanism.

摘要

在大鼠中，已表明茶碱可增强吗啡对撤除刺激后发声阈值的作用。这种对疼痛刺激的反应被认为是在丘脑 - 下丘脑 - 嗅脑水平整合的。纳洛酮拮抗了吗啡与茶碱联合治疗的效果，提示对吗啡具有药理学特异性。此外，匹莫齐特预处理后，茶碱诱导的对吗啡这种药理学反应增强作用减弱，表明存在潜在的多巴胺能机制。

相似文献

1
Naloxone antagonizes theophylline-induced potentiation of morphine inhibition of a nociceptive reaction in rats.纳洛酮可拮抗茶碱诱导的吗啡对大鼠伤害性反应抑制作用的增强。
Psychopharmacology (Berl). 1979 Apr 25;62(3):235-9. doi: 10.1007/BF00431953.
2
Morphine-theophylline interaction: antagonism or facilitation?吗啡-茶碱相互作用：拮抗还是协同？
Br J Pharmacol. 1981 Aug;73(4):887-92. doi: 10.1111/j.1476-5381.1981.tb08742.x.
3
Enhancement of apomorphine-induced inhibition of vocalisation afterdischarge response by theophylline.茶碱增强阿扑吗啡诱导的发声后放电反应抑制作用。
Life Sci. 1975 Oct 10;17(7):1145-51. doi: 10.1016/0024-3205(75)90337-9.
4
Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide.纳洛酮和匹莫齐特可减弱吗啡条件性多动的表达。
Psychopharmacology (Berl). 1987;93(3):314-9. doi: 10.1007/BF00187249.
5
Enhanced analgesic effects of morphine after chronic administration of naloxone in the rat.大鼠长期给予纳洛酮后吗啡镇痛作用增强
Eur J Pharmacol. 1978 Feb 15;47(4):473-4. doi: 10.1016/0014-2999(78)90131-0.
6
Opioid-neuroleptic interaction in brainstem self-stimulation.脑干自我刺激中的阿片类药物与抗精神病药物相互作用
Brain Res. 1989 Jan 16;477(1-2):144-51. doi: 10.1016/0006-8993(89)91401-7.
7
Quasi morphine-abstinence syndrome.类吗啡戒断综合征
Nature. 1974 May 31;249(456):471-3. doi: 10.1038/249471a0.
8
[Effect of morphine and pentazocine on emotional-behavioral and hemodynamic nociceptive reactions].
Farmakol Toksikol. 1987 Jan-Feb;50(1):27-30.
9
Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats.
Pain. 1990 Jun;41(3):353-363. doi: 10.1016/0304-3959(90)90012-3.
10
[Influence of klofelin on the analgesic effect of morphine].[克洛菲林对吗啡镇痛效果的影响]
Farmakol Toksikol. 1986 Jan-Feb;49(1):40-4.

本文引用的文献

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Observations on the neuropharmacology of morphine and morphinelike analgesia.关于吗啡及类吗啡镇痛的神经药理学观察
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2
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.抗精神病药物治疗后多巴胺和去甲肾上腺素的受体活性及更新率
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Morphine catalepsy in the rat: relation to striatal dopamine metabolism.大鼠体内的吗啡僵住症：与纹状体多巴胺代谢的关系。
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Dopamine in the mesolimbic system of the rat brain: endogenous levels and the effects of drugs on the uptake mechanism and stimulation of adenylate cyclase activity.大鼠脑边缘系统中的多巴胺：内源性水平以及药物对摄取机制和腺苷酸环化酶活性刺激的影响。
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5
Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by L-DOPA plus decarboxylase inhibition.双侧尾状核和壳核区域注射6-羟基多巴胺后吗啡镇痛作用减弱，僵住作用增强；左旋多巴加脱羧酶抑制可部分恢复。
Neuropharmacology. 1973 Dec;12(12):1153-60. doi: 10.1016/0028-3908(73)90072-5.
6
The effects of caffeine and theophylline on nociceptive stimulation in the rat.咖啡因和茶碱对大鼠伤害性刺激的影响。
Acta Pharmacol Toxicol (Copenh). 1973;32(1):22-32. doi: 10.1111/j.1600-0773.1973.tb01448.x.
7
Theophylline increased sensitivity to nociceptive stimulation and regional turnover of rat brain 5-HT, noradrenaline and dopamine.茶碱增加了大鼠对伤害性刺激的敏感性以及脑内5-羟色胺、去甲肾上腺素和多巴胺的局部更新率。
Acta Pharmacol Toxicol (Copenh). 1974 Mar;34(3):157-73. doi: 10.1111/j.1600-0773.1974.tb03494.x.
8
Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".大鼠脑尾状核中对多巴胺敏感的腺苷酸环化酶及其与“多巴胺受体”的相似性。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2145-9. doi: 10.1073/pnas.69.8.2145.
9
Evidence for dopamine receptor stimulation by apomorphine.阿扑吗啡对多巴胺受体刺激作用的证据。
J Pharm Pharmacol. 1967 Sep;19(9):627-9. doi: 10.1111/j.2042-7158.1967.tb09604.x.
10
The influence of caffeine on d-amphetamine- and apomorphine-induced stereotyped behavior.咖啡因对右旋苯丙胺和阿扑吗啡诱导的刻板行为的影响。
Life Sci. 1974 Apr 16;14(8):1493-500. doi: 10.1016/0024-3205(74)90160-x.