Kerr F W
J Comp Neurol. 1975 Feb 1;159(3):335-56. doi: 10.1002/cne.901590304.
The ascending degeneration resulting from experimental lesions of the ventral funiculus of the spinal cord of Macaca mulatta has been studied using the Nauta technique and its variants. The ventral spinothalamic tract is shown to be an independent entity with respect to the lateral spinothalamic tract; its fibers are widely distributed in the ventral funiculus and it establishes connections with the brain stem and thalamus which are analogous but not identical to those of the latter. Its role in the relay of nociceptive input is discussed in view of the similarity in hodology of the two systems and it is proposed that it may be responsible for the failure of anterolateral cordotomy to control pain on a long term basis. Other ascending systems in the ventral funiculus include the spino-olivary and spino-reticular tracts, as well as minor connections to the N. of Edinger-Westphal, the red nucleus and the superior colliculus. The projections from the ventral quadrant of the spinal cord to the brain stem are almost entirely ipsilateral until the rostral mesencephalon is reached, at which level the N. of Darkschewitz receives both ipsilateral and crossed input; the magnocellular nucleus of the medial geniculate body receives a small contribution which is mainly ipsilateral. In the thalamus the VPL receives predominantly ipsilateral projections while the input to the paralaminar nuclei is only slightly less pronounced contralaterally than ipsilaterally.
利用纳塔技术及其变体，对恒河猴脊髓腹侧索实验性损伤所致的上行性变性进行了研究。腹侧脊髓丘脑束相对于外侧脊髓丘脑束而言是一个独立的实体；其纤维广泛分布于腹侧索，并与脑干和丘脑建立联系，这些联系与后者类似但并不相同。鉴于这两个系统在神经传导路径学上的相似性，讨论了其在伤害性传入中继中的作用，并提出它可能是脊髓前外侧切断术长期无法控制疼痛的原因。腹侧索中的其他上行系统包括脊髓橄榄束和脊髓网状束，以及与动眼神经副核、红核和上丘的少量联系。直到到达中脑嘴侧，脊髓腹侧象限向脑干的投射几乎完全是同侧的，在这个水平，达克施维茨核接受同侧和交叉输入；内侧膝状体大细胞核接受少量主要为同侧的投射。在丘脑中，腹后外侧核主要接受同侧投射，而对板内核的输入，其对侧与同侧的差异仅略小。
