Catts S V, Fox A M, Ward P B, McConaghy N
School of Psychiatry, University of New South Wales, Sydney, Australia.
Aust N Z J Psychiatry. 2000 Nov;34 Suppl:S101-7. doi: 10.1080/000486700229.
To evaluate measures of schizotypy as familial risk factors for schizophrenia with the aim of making recommendations for assessing schizotypy as part of screening procedures for identifying people at risk of schizophrenia.
Published studies using self-report and interview-based measures of schizotypy to assess relatives of patients with schizophrenia are reviewed. A parent study is reported evaluating the diagnostic accuracy of parental schizotypy as assessed by three questionnaire-based measures: the Chapman Perceptual Aberration and Physical Anhedonia Scales, and the Eysenck Psychoticism Scale. Group scores for these self-report ratings of 23 parent-pairs of patients with schizophrenia, 20 parent-pairs of patients with chronic nonpsychotic psychiatric disorder, and 19 parent-pairs of healthy comparison subjects are compared.
Consistent with published evidence that self-report measures of psychosis-proneness and schizotypy do not consistently reflect familial risk factors that are specific for schizophrenia, scores on questionnaire measures of schizotypy did not distinguish the parents of patients with schizophrenia from the parents in the other two groups.
Interview-based assessments of schizotypy better assess familial risk factors than self-report measures of schizotypy. Questionnaire measures of schizotypy should be supplemented by interview-based assessments when screening for individuals at risk of schizophrenia.
评估精神分裂症型人格特质作为精神分裂症家族风险因素的指标，旨在为将精神分裂症型人格特质评估作为识别精神分裂症风险人群筛查程序的一部分提供建议。
回顾已发表的使用基于自我报告和访谈的精神分裂症型人格特质测量方法来评估精神分裂症患者亲属的研究。报告一项母研究，该研究评估了通过三种基于问卷的测量方法所评估的父母精神分裂症型人格特质的诊断准确性：查普曼知觉偏差和躯体快感缺乏量表，以及艾森克精神质量表。比较了23对精神分裂症患者父母、20对慢性非精神病性精神障碍患者父母和19对健康对照受试者父母的这些自我报告评分的组分数。
与已发表的证据一致，即自我报告的精神病易感性和精神分裂症型人格特质测量方法不能始终反映精神分裂症特有的家族风险因素，精神分裂症型人格特质问卷测量的分数并不能区分精神分裂症患者的父母与其他两组的父母。
与基于自我报告的精神分裂症型人格特质测量方法相比，基于访谈的精神分裂症型人格特质评估能更好地评估家族风险因素。在筛查精神分裂症风险个体时，精神分裂症型人格特质的问卷测量应辅以基于访谈的评估。
