Hecht A
Psychopharmacology (Berl). 1979 Apr 25;62(3):301-5. doi: 10.1007/BF00431962.
The behavioral effects produced by chronic treatment with alpha-flupenthixol decanoate followed by a 3-month pause upon social interaction in a group of eight rats were studied. alpha-Flupenthixol decanoate induced total disruption of two of the group formations studied, i.e., three or more in a group outside a corner and three or more following (running in a row)--the overall behavioral change shows a general depressive effect of the drug and a change in the pattern of social interaction. The shift in balance between the behavioral categories measured appeared as a significant difference in the time spent in the various group formations. Disintegration of group coherence, as shown in the measures of the degree of isolation, appeared only in the alpha-flupenthixol decanoate-treated group. An apomorphine test, which concluded the experiment 3 months after the last alpha-flupenthixol decanoate injection, revealed a significant difference in relation to licking response between the test group and the control group. The apomorphine test reported in this paper showed effects up to 90 days after the last drug treatment.
研究了癸酸氟奋乃静长期治疗八只大鼠后，停药3个月对其社交互动行为产生的影响。癸酸氟奋乃静导致所研究的两种群体结构完全瓦解，即角落外一组三只或更多只以及三只或更多只依次排列（连续奔跑）——总体行为变化显示出该药物具有普遍的抑郁作用以及社交互动模式的改变。所测量的行为类别之间平衡的变化表现为在各种群体结构中所花费时间的显著差异。如隔离程度测量所示，群体凝聚力的瓦解仅出现在癸酸氟奋乃静治疗组中。在最后一次注射癸酸氟奋乃静3个月后进行的阿扑吗啡试验表明，试验组与对照组在舔舐反应方面存在显著差异。本文报道的阿扑吗啡试验显示，在最后一次药物治疗后长达90天仍有效果。
