Sahakian B J, Robbins T W, Iversen S D
Eur J Pharmacol. 1976 May;37(1):169-78. doi: 10.1016/0014-2999(76)90019-4.
Socially reared and isolation-reared rats treated chronically since weaning with alpha-flupenthixol showed elevated levels of spontaneous locomotor activity compared with control treated rats. However, chronic apomorphine treatment had no effect on spontaneous locomotor activity. Chronic alpha-flupenthixol treatment enhanced stereotyped behaviour after 1.5 mg/kg d-amphetamine or 0.5 mg/kg apomorphine in the socially reared condition. 'Spontaneous stereotypies' were also observed in the chronic alpha-flupenthixol-treated animals. Chronic apomorphine treatment did not affect stereotyped responding. The results are discussed in terms of 'behavioural supersensitivity'.
自断奶起长期用α-氟奋乃静治疗的群居饲养和隔离饲养大鼠，与接受对照治疗的大鼠相比，其自发运动活动水平升高。然而，长期阿扑吗啡治疗对自发运动活动没有影响。在群居饲养条件下，长期α-氟奋乃静治疗增强了1.5mg/kg右旋苯丙胺或0.5mg/kg阿扑吗啡后的刻板行为。在长期接受α-氟奋乃静治疗的动物中也观察到了“自发刻板行为”。长期阿扑吗啡治疗不影响刻板反应。根据“行为超敏反应”对结果进行了讨论。
