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微创视频辅助甲状旁腺切除术:137例经验教训

Minimally invasive video-assisted parathyroidectomy: lesson learned from 137 cases.

作者信息

Miccoli P, Berti P, Conte M, Raffaelli M, Materazzi G

机构信息

Department of Surgery, University of Pisa, Italy.

出版信息

J Am Coll Surg. 2000 Dec;191(6):613-8. doi: 10.1016/s1072-7515(00)00737-7.

Abstract

BACKGROUND

Since February 1997, a technique of minimally invasive video-assisted parathyroidectomy (MIVAP) was developed at our institution for the treatment of sporadic primary hyperparathyroidism (sPHPT). In this study we analyzed the entire series of patients who underwent MIVAP during the last 3 years.

STUDY DESIGN

One hundred thirty-seven patients with sPHPT were selected for MIVAP. Selection criteria were: diagnosis of single adenoma based on preoperative localization studies (ultrasonography, sestamibi scintigraphy, or both), and no previous neck surgery or concomitant large multinodular goiter. The procedure, already described, is performed by a gasless video-assisted technique through a single 1.5-cm central skin incision above the sternal notch. Quick, intraoperative parathyroid hormone assay was used in 134 cases (97.8%) to confirm the complete removal of all hyperfunctioning parathyroid tissue.

RESULTS

Mean operative time was 54.3 +/- 22.6 minutes. The conversion rate was 8.8%. One laryngeal nerve palsy was registered (0.7%), as was one case of persistent hyperparathyroidism. In six patients (4.4%) a transient symptomatic postoperative hypocalcemia was observed. Two thyroid lobectomies were associated using the same minimally invasive access. At a mean followup of 15.4 +/- 10.6 months, all but two patients were normocalcemic. The cosmetic result was considered excellent by most of the patients (92.8%).

CONCLUSIONS

Although not all patients with sPHPT are eligible for MIVAP, this approach can now be proposed in a bigger proportion (67% of patients). As already demonstrated in a previous study, also in a large series of patients, after greater experience has been achieved, the results and the operative time are the same as in traditional surgery, with better cosmetic result and a less painful course.

摘要

背景

自1997年2月起,我院开展了一种微创电视辅助甲状旁腺切除术(MIVAP)技术用于治疗散发性原发性甲状旁腺功能亢进症(sPHPT)。在本研究中,我们分析了过去3年中接受MIVAP治疗的所有患者。

研究设计

选择137例sPHPT患者接受MIVAP治疗。选择标准为:根据术前定位检查(超声、锝-99m甲氧基异丁基异腈闪烁扫描或两者皆用)诊断为单发腺瘤,且既往无颈部手术史或合并巨大结节性甲状腺肿。该手术已作描述,通过在胸骨切迹上方作一个1.5厘米的中央皮肤小切口,采用无气电视辅助技术进行。134例(97.8%)患者术中采用快速甲状旁腺激素测定以确认所有功能亢进的甲状旁腺组织已被完全切除。

结果

平均手术时间为54.3±22.6分钟。中转率为8.8%。记录到1例喉返神经麻痹(0.7%),1例持续性甲状旁腺功能亢进。6例患者(4.4%)术后出现短暂性有症状的低钙血症。使用相同的微创入路进行了2例甲状腺叶切除术。平均随访15.4±10.6个月时,除2例患者外,其余患者血钙均正常。大多数患者(92.8%)认为美容效果极佳。

结论

虽然并非所有sPHPT患者都适合MIVAP,但现在可以对更大比例(67%的患者)的患者采用这种方法。正如先前一项研究中所证实的,在大量患者中,随着经验的积累,结果和手术时间与传统手术相同,美容效果更好,病程痛苦更小。

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