Milman N, Byg K E, Ovesen L
Copenhagen County Center for Prevention of Disease, Glostrup Hospital, Universit of Copenhagen, Denmark.
Ann Hematol. 2000 Nov;79(11):612-21. doi: 10.1007/s002770000209.
Iron status, i.e. serum ferritin and haemoglobin (Hb) levels, was assessed in a population survey in 1994 (Dan-Monica 10) comprising 1319 Caucasian Danish women in age cohorts of 40, 50, 60 and 70 years. In the entire series, ferritin levels increased significantly from 40 years to 60 years of age. The prevalence of small iron stores (ferritin 16-32 microg/l), depleted iron stores (ferritin < 16 microg/l) and of iron deficiency anaemia (ferritin < 13 microg/l and Hb < 121 g/l) decreased steadily with age. Blood donors (n = 109) had lower ferritin levels than non-donors (P<0.0001). Ferritin levels in donors were inversely correlated with the cumulated number of lifetime phlebotomies (r(s) = -0.25, P<0.01). Ferritin levels in non-donors (n = 1208) were low in 40-year-old women (median 40 microg/l) and increased to a median of 95 microg/l in 60- and 70-year-old women (P<0.0001). In non-donors 40 years of age, the prevalence of small iron stores was 40.4%, the prevalence of depleted iron stores 10.8% and the prevalence of iron deficiency anaemia 2.16%. The prevalence of iron overload (ferritin >300 microg/l) was 1.54%. Ferritin levels in 60- and 70-year-old non-donors were correlated with the body mass index (r(s) =0.11, P=0.01). Ferritin levels in 50- to 60-year-old non-donors were correlated with alcohol intake (r(s)=0.23, P<0.0001). In the entire series, 37.5% of non-donors took supplemental ferrous iron (median 14 mg iron per day). Iron supplements had a significant positive influence on iron status in 40-year-old premenopausal non-donors but no effect in postmenopausal women or in donors. Non-donors (n = 170) treated with acetylsalicylic acid had lower ferritin levels (median 55 microg/l) than non-treated (n = 1038; median 75 microg/l) (P<0.0001). Compared with the Dan-Monica 1 iron status survey in 1984, the prevalence of iron deficiency and iron deficiency anaemia was unchanged, whereas the prevalence of iron overload displayed a slight increase. The 1987 abolition of the mandatory iron fortification of flour apparently had no negative effect on iron status.
1994年在一项人群调查（丹麦-莫妮卡10）中对铁状态，即血清铁蛋白和血红蛋白（Hb）水平进行了评估，该调查涵盖了1319名40、50、60和70岁年龄组的丹麦白人女性。在整个队列中，铁蛋白水平从40岁到60岁显著升高。小铁储备（铁蛋白16 - 32微克/升）、缺铁储备（铁蛋白<16微克/升）和缺铁性贫血（铁蛋白<13微克/升且Hb<121克/升）的患病率随年龄稳步下降。献血者（n = 109）的铁蛋白水平低于非献血者（P<0.0001）。献血者的铁蛋白水平与终生放血累积次数呈负相关（r(s)= -0.25，P<0.01）。非献血者（n = 1208）中，40岁女性的铁蛋白水平较低（中位数40微克/升），60岁和70岁女性的铁蛋白水平升至中位数95微克/升（P<0.0001）。在40岁的非献血者中，小铁储备的患病率为40.4%，缺铁储备的患病率为10.8%，缺铁性贫血的患病率为2.16%。铁过载（铁蛋白>300微克/升）的患病率为1.54%。60岁和70岁非献血者的铁蛋白水平与体重指数相关（r(s)=0.11，P = 0.01）。50至60岁非献血者的铁蛋白水平与酒精摄入量相关（r(s)=0.23，P<0.0001）。在整个队列中，37.5%的非献血者服用铁补充剂（每天铁中位数14毫克）。铁补充剂对40岁绝经前非献血者的铁状态有显著的积极影响，但对绝经后女性或献血者没有影响。服用乙酰水杨酸治疗的非献血者（n = 170）的铁蛋白水平（中位数55微克/升）低于未治疗者（n = 1038；中位数75微克/升）（P<0.0001）。与1984年的丹麦-莫妮卡1铁状态调查相比，缺铁和缺铁性贫血的患病率没有变化，而铁过载的患病率略有增加。1987年面粉强制铁强化的废除显然对铁状态没有负面影响。
