母体和脐带血清中的瘦素水平：与胎儿发育及胎盘重量的关系。

Leptin levels in maternal and cord serum: relationship with fetal development and placental weight.

作者信息

Papadopoulou F G, Mamopoulos A M, Triantos A, Constantinidis T C, Papadimas J, Assimakopoulos E A, Koliakos G, Mamopoulos M

机构信息

Department of Endocrinology Panagia Hospital of Thessaloniki, Greece.

出版信息

J Matern Fetal Med. 2000 Sep-Oct;9(5):298-302. doi: 10.1002/1520-6661(200009/10)9:5<298::AID-MFM9>3.0.CO;2-P.

DOI:10.1002/1520-6661(200009/10)9:5<298::AID-MFM9>3.0.CO;2-P

PMID:11132587

Abstract

OBJECTIVE

To test the hypothesis that the circulating levels of leptin in the maternal and cord serum correlate with the birthweight of the newborns and with the weight of the placenta.

METHODS

In a population of 85 women from northern Greece who gave birth to an equal number of full-term infants, we calculated the concentration of leptin in the maternal serum as well as in the cord serum, right after delivery, by using an immunoradiometric assay. The correlation between these values, the maternal BMI before pregnancy and at the time of delivery, the neonatal BMI, Ponderal Index, and the placental weight was studied.

RESULTS

Mean maternal leptin showed a statistically significant difference from mean cord serum leptin (14.7 and 7.07 ng/ml, respectively) and was positively correlated to the maternal BMI at the time of delivery (r = 0.3, P = 0.016), but not to neonatal BMI. A positive correlation between the mean cord serum leptin and the BMI of the neonates (r = 0.26, P = 0.031 ) was found. There was no correlation between the maternal BMI at the time of delivery and the neonatal BMI. Similarly, no correlation could be established between the placental weight and the levels of leptin in the maternal or in the cord serum but a positive correlation between placental weight, neonatal BMI and weight, and mothers' BMI was observed. Finally, although a noteworthy difference between the mean leptin levels of neonates of two different sexes was observed (male 5.9 ng/ml, female 7.8 ng/ml), that difference never reached a statistically significant level.

CONCLUSIONS

The maternal leptin level could not be used as a reliable marker of fetal growth but a positive correlation between cord serum leptin and fetus growth is suggested.

摘要

目的

验证母体血清和脐带血清中瘦素的循环水平与新生儿出生体重及胎盘重量相关的假说。

方法

在希腊北部85名分娩出同等数量足月儿的女性群体中，我们在分娩后立即采用免疫放射分析方法计算母体血清以及脐带血清中瘦素的浓度。研究了这些数值之间、孕前及分娩时母体的体重指数（BMI）、新生儿BMI、 ponderal指数和胎盘重量之间的相关性。

结果

母体瘦素平均水平与脐带血清瘦素平均水平存在统计学显著差异（分别为14.7和7.07 ng/ml），且与分娩时母体BMI呈正相关（r = 0.3，P = 0.016），但与新生儿BMI无关。发现脐带血清瘦素平均水平与新生儿BMI呈正相关（r = 0.26，P = 0.031）。分娩时母体BMI与新生儿BMI之间无相关性。同样，胎盘重量与母体或脐带血清中瘦素水平之间未发现相关性，但观察到胎盘重量与新生儿BMI、体重以及母亲BMI之间呈正相关。最后，尽管观察到两种不同性别的新生儿瘦素平均水平存在显著差异（男性5.9 ng/ml，女性7.8 ng/ml），但该差异从未达到统计学显著水平。