Clapp J F, Kiess W
Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, Ohio 44109, USA.
J Soc Gynecol Investig. 1998 Nov-Dec;5(6):300-3.
To explore the relationship between leptin levels and fat mass at the time of birth to test the hypothesis that the level of leptin in the fetal circulation is primarily an index of fetal fat mass.
Leptin concentration was measured in cord blood obtained from the offspring of 42 women. Trimmed, drained placental weight and neonatal morphometrics were obtained after delivery.
The ranges in maternal weight (46.7-93.2 kg), weight gain (3.2-22.6 kg), percent body fat (10-34%), placental weight (290-688 g), birth weight (2.63-4.32 kg), neonatal fat mass (179-782 g), and cord blood leptin (1.7-26.7 ng/mL) were wide. The only morphometric variable that explained a significant portion of the variation in cord blood leptin levels was neonatal fat mass (r2 = 0.41), and this relationship was not significantly improved by best subset regression of additional fetal and placental morphometric variables (r2 = 0.46).
These data support the hypothesis and suggest that in the fetus, as in the child and the adult, fat mass is the major determinant of circulating leptin levels.
探讨出生时瘦素水平与脂肪量之间的关系，以验证胎儿循环中瘦素水平主要是胎儿脂肪量指标这一假说。
测量了42名女性后代脐带血中的瘦素浓度。分娩后获取了修整、沥干后的胎盘重量和新生儿形态学指标。
母亲体重（46.7 - 93.2千克）、体重增加量（3.2 - 22.6千克）、体脂百分比（10 - 34%）、胎盘重量（290 - 688克）、出生体重（2.63 - 4.32千克）、新生儿脂肪量（179 - 782克）和脐带血瘦素（1.7 - 26.7纳克/毫升）的范围都很广。唯一能解释脐带血瘦素水平显著部分变异的形态学变量是新生儿脂肪量（r² = 0.41），并且通过对额外的胎儿和胎盘形态学变量进行最佳子集回归，这种关系并未得到显著改善（r² = 0.46）。
这些数据支持了该假说，并表明在胎儿中，如同在儿童和成人中一样，脂肪量是循环瘦素水平的主要决定因素。
