Drăgoi T, Saragea A, Michel I, Iancu L
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1979 Jan-Mar;24(1):15-22.
A number of 700 guinea pigs were immunized by parenteral route with non-toxigenic Corynebacterium diphtheriae strains, then inoculated with various doses of homologous and heterologous toxigenic C. diphitheriae strains. The results showed that non-toxigenic C. diphtheriae strains confer a certain degree of protection when the challenge is done with homologous toxigenous strains, especially when not more than 500 million germs/ml are used for the challenge dose. This suggests that the carriage of non-toxigenic diphtheriae bacilli is a useful phenomenon for maintaining an immune balance in diphtheria in the present epidemiological context, and that their sterilization is not opportune.
700只豚鼠通过非产毒性白喉棒状杆菌菌株经肠胃外途径进行免疫，然后接种不同剂量的同源和异源产毒性白喉棒状杆菌菌株。结果表明，当用同源产毒菌株进行攻击时，非产毒性白喉棒状杆菌菌株可提供一定程度的保护，尤其是当攻击剂量不超过每毫升5亿个细菌时。这表明，在当前的流行病学背景下，携带非产毒性白喉杆菌对于维持白喉的免疫平衡是一种有益现象，对白喉杆菌进行除菌并不适宜。
