使用青霉素最低抑菌浓度预测其他β-内酰胺类抗菌药物对肺炎链球菌的体外活性。
Use of penicillin MICs to predict in vitro activity of other beta-lactam antimicrobial agents against Streptococcus pneumoniae.
作者信息
Brueggemann A B, Pfaller M A, Doern G V
机构信息
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
出版信息
J Clin Microbiol. 2001 Jan;39(1):367-9. doi: 10.1128/JCM.39.1.367-369.2001.
Abstract
Linear regression analysis was used to compare penicillin MICs determined with 3,129 recent clinical isolates of Streptococcus pneumoniae to MICs obtained with nine other beta-lactam antimicrobial agents. A strong correlation between penicillin MICs and those obtained with other beta-lactams was demonstrated. It may be possible to test penicillin and use MICs obtained with penicillin to predict MICs of other beta-lactam antimicrobials for Streptococcus pneumoniae.
摘要
采用线性回归分析，将3129株近期临床分离的肺炎链球菌的青霉素最低抑菌浓度（MIC）与其他9种β-内酰胺类抗菌药物的MIC进行比较。结果显示，青霉素MIC与其他β-内酰胺类药物的MIC之间存在强相关性。对于肺炎链球菌，有可能通过检测青霉素并利用其MIC来预测其他β-内酰胺类抗菌药物的MIC。
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