受辐照小鼠胸腺和脾脏的染色质对碱性溶液的敏感性。
The sensitivity of chromatin from thymuses and spleens of irradiated mice to alkaline solutions.
作者信息
Skalka M, Cejková M, Matyásová J
出版信息
Folia Biol (Praha). 1976;22(5):335-42.
Increasing amounts of DNA and proteins are released from the suspensions of chromatin from thymuses and spleens of irradiated mice (6 hours after 600R whole-body) by the action of alkaline solutions (pH 8-10) at physiological ionic strengths. The suspension of chromatin from normal tissues releases in this pH range only a small amount of proteins and negligible amount of DNA. The behaviour of liver and kidney chromatin to alkaline solutions shows no difference between normal and irradiated tissues. The time of onset and dose relation of the increased sensitivity of thymus and spleen chromatin from irradiated mice to alkaline solutions show a similar course as earlier described signs of postirradiation damage to chromatin of these tissues.
在生理离子强度下，通过碱性溶液（pH 8 - 10）的作用，照射后小鼠（全身600伦琴照射6小时后）胸腺和脾脏染色质悬浮液中释放出越来越多的DNA和蛋白质。正常组织染色质悬浮液在此pH范围内仅释放少量蛋白质和可忽略不计的DNA。肝脏和肾脏染色质对碱性溶液的反应在正常组织和照射组织之间没有差异。照射小鼠胸腺和脾脏染色质对碱性溶液敏感性增加的起始时间和剂量关系与这些组织染色质辐射后损伤的早期迹象呈现相似的过程。
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