Hollatz R, Tempel K
Radiat Environ Biophys. 1978 Mar 30;15(1):77-83. doi: 10.1007/BF01330901.
Unscheduled DNA-synthesis of UV-irradiated spleen lymphocytes of the rat is inhibited in a dose-dependent manner by total-body X-irradiation. The reaction is observed immediately after exposure and reaches its maximum within 8--16 h. Doses of some rads are detectable. Following sublethal X-irradiation (250 rad), regeneration takes 4--6 weeks. Analogous results have been obtained in rats treated with 2,4,6-triethyleneimino-1,3,5-triazine. Regardless of the action mechanisms, it is concluded from the present results that the inhibition of the unscheduled incorporation of thymidine-3H in splenic lymphocytes is a very sensitive, though not specific expression of impairment of the lymphatic system.
大鼠经紫外线照射的脾淋巴细胞的非预定DNA合成，受到全身X射线照射的剂量依赖性抑制。该反应在照射后立即观察到，并在8-16小时内达到最大值。一些拉德的剂量是可检测到的。经亚致死剂量的X射线照射（250拉德）后，再生需要4-6周。在用2,4,6-三乙撑亚胺基-1,3,5-三嗪处理的大鼠中也得到了类似的结果。无论作用机制如何，从目前的结果可以得出结论，脾淋巴细胞中3H-胸腺嘧啶核苷非预定掺入的抑制是淋巴系统损伤的一种非常敏感但非特异性的表现。
