Portier F, Hsu W C, Herman P, Tran Ba Huy P
Clinique d'ORL et de Chirurgie Cervico-Faciale. Hôpital Lariboisière, 2, rue Ambroise Paré, 75010, Paris, France.
Auris Nasus Larynx. 2001 Jan;28(1):3-7. doi: 10.1016/s0385-8146(00)00097-3.
Secretory otitis media is defined by a chronic effusion in the middle ear cavities, behind an intact tympanic membrane without acute infection. In the course of secretory otitis media, the effusion is sometimes thick (or mucoid) and other times thin (or serous). For several authors, these differences might be related to different inflammatory levels rather than to distinct pathophysiological mechanisms. The purpose of this study was to determine whether the modulation of ion transport by inflammation could account for the differences observed in the aspect of ME effusion.
Hydrogen peroxide (H2O2), used as an inflammation model was tested on a middle ear cell line (MESV) in culture.
Results show that low and high concentrations of H2O2 have opposite effects on ion (and then water) absorption by the middle ear epithelium.
the modulation of ion and water absorption by inflammation could modify the mucins concentration in the effusion, and explain observed viscosity differences in the course of secretory otitis media.
分泌性中耳炎的定义为中耳腔内存在慢性积液，鼓膜完整且无急性感染。在分泌性中耳炎病程中，积液有时浓稠（或呈黏液样），有时稀薄（或呈浆液性）。一些作者认为，这些差异可能与不同的炎症水平有关，而非不同的病理生理机制。本研究的目的是确定炎症对离子转运的调节是否能够解释在中耳积液外观上观察到的差异。
以过氧化氢（H₂O₂）作为炎症模型，在培养的中耳细胞系（MESV）上进行测试。
结果表明，低浓度和高浓度的H₂O₂对中耳上皮细胞的离子（进而对水）吸收有相反的影响。
炎症对离子和水吸收的调节可能会改变积液中的黏蛋白浓度，并解释分泌性中耳炎病程中观察到的黏度差异。
