Gasztonyi B, Pár A, Szomor A, Nagy A, Kereskai L, Losonczy H, Pajor L, Horanyi M, Mózsik G
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, I. Belgyógyászati Klinika.
Orv Hetil. 2000 Dec 3;141(49):2649-51.
Oncogenesis is a multifactorial process in which environmental, genetical and infectious factors may be of importance. Specific viruses are supposed to have etiological role in about 15% of human tumors. Recently the B-cell proliferation inducing effect of the hepatotropic and lymphotropic hepatitis-C virus (HCV) came into the limelight based on the high prevalence of HCV positivity in B-cell non-Hodgkin's lymphoma (NHL) patients. The aim of the authors was to establish the prevalence of HCV infection in NHL patients. Paralelly the HBV, CMV and EBV markers, and the alterations of the humoral immune response (immunoglobulins, cryoglobulins, rheumatoid factor) were determined. 42 patients (24 male, 18 female; the mean age: 54.1 years, range 22-80 years) classified as 16 indolent (low risk), and 25 aggressive (intermediate risk) NHL and one with very aggressive Burkitt's lymphoma, according to the modified REAL classification were examined. Enzyme-linked immunosorbent assay (ELISA) for HBsAg and anti-HCV, HBsAg, anti EBV, anti CMV, furthermore polymerase chain reaction (PCR) for HCV-RNA were used. Anti-HCV was found in 6/42 NHL patients (14.3%), while anti-HCV and/or HCV-RNA PCR positivity revealed on overall HCV infection in 10/42 (23.8%) patients. None of them were HBsAg positive. Our findings support the hypothesis, that HCV might have an aetiological role in the lymphoproliferation leading to B-cell NHL.
肿瘤发生是一个多因素过程，其中环境、遗传和感染因素可能具有重要作用。特定病毒被认为在约15%的人类肿瘤中具有病因学作用。最近，基于丙型肝炎病毒（HCV）在B细胞非霍奇金淋巴瘤（NHL）患者中的高阳性率，嗜肝和嗜淋巴细胞的HCV的B细胞增殖诱导作用受到关注。作者的目的是确定NHL患者中HCV感染的患病率。同时还测定了HBV、CMV和EBV标志物以及体液免疫反应（免疫球蛋白、冷球蛋白、类风湿因子）的变化。根据改良的REAL分类法，对42例患者（24例男性，18例女性；平均年龄：54.1岁，范围22 - 80岁）进行了检查，其中16例为惰性（低风险）NHL，25例为侵袭性（中度风险）NHL，1例为高度侵袭性的伯基特淋巴瘤。采用酶联免疫吸附测定（ELISA）检测HBsAg和抗HCV、HBsAg、抗EBV、抗CMV，此外采用聚合酶链反应（PCR）检测HCV - RNA。42例NHL患者中有6例（14.3%）抗HCV阳性，而抗HCV和/或HCV - RNA PCR阳性显示10/42（23.8%）患者存在总体HCV感染。他们均无HBsAg阳性。我们的研究结果支持这样的假设，即HCV可能在导致B细胞NHL的淋巴细胞增殖中具有病因学作用。
