T淋巴细胞中RANTES表达的转录调控

Transcriptional regulation of RANTES expression in T lymphocytes.

作者信息

Song A, Nikolcheva T, Krensky A M

机构信息

Department of Pediatrics, Stanford University, California 94305-5164, USA.

出版信息

Immunol Rev. 2000 Oct;177:236-45. doi: 10.1034/j.1600-065x.2000.17610.x.

DOI:10.1034/j.1600-065x.2000.17610.x

PMID:11138780

Abstract

We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes "late", 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such "late" expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Krüppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is "late" after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.

摘要

我们最初将RANTES趋化因子确定为寻找T淋巴细胞在激活后3至5天“晚期”表达的基因的一部分。RANTES和其他少数基因的表达动力学不同寻常，这种延迟表达的机制尚不清楚。为了揭示这种“晚期”表达的机制，我们鉴定并表征了RANTES启动子以及一种调节T淋巴细胞中RANTES表达的新型转录因子。晚期活化T淋巴细胞的RANTES因子（RFLAT）-1是Krüppel样转录因子家族的成员。与RANTES一样，RFLAT-1的表达在T细胞激活后是“晚期”的。但是，与RANTES不同，RFLAT-1表达的调节似乎是翻译水平而非转录水平的。