Morrow L A, Gibson C, Bagovich G R, Stein L, Condray R, Scott A
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Psychosom Med. 2000 Nov-Dec;62(6):746-50. doi: 10.1097/00006842-200011000-00002.
The purpose of this study was to determine whether the prevalence of current and past DSM-IV axis I psychiatric disorders is higher among persons with a history of exposure to organic solvents than among a demographically similar group of nonexposed control subjects.
Thirty-eight solvent-exposed subjects and 39 nonexposed healthy control subjects were evaluated for axis I disorder with the Structured Clinical Interview for DSM-IV.
A significantly higher number of solvent-exposed subjects (71%) met criteria for current DSM-IV axis I disorder in comparison with control subjects (10%). The most prevalent diagnosis in exposed subjects was within the anxiety and mood clusters, with a high percentage (36%) of exposed subjects meeting criteria for a dual diagnosis of mood and anxiety disorder. There were no differences between the groups in past psychiatric disorders or current or past substance abuse or dependence.
The rates of past psychiatric disorders among solvent-exposed subjects are similar to those among normal control subjects, but the prevalence of current DSM-IV axis I psychiatric disorders is significantly higher among exposed subjects than among control subjects.
本研究旨在确定有有机溶剂接触史的人群中，当前及既往《精神疾病诊断与统计手册》第四版（DSM-IV）轴I精神障碍的患病率是否高于在人口统计学特征上与之相似的未接触对照组人群。
采用DSM-IV结构化临床访谈，对38名有溶剂接触史的受试者和39名未接触的健康对照受试者进行轴I障碍评估。
与对照受试者（10%）相比，有溶剂接触史的受试者中符合当前DSM-IV轴I障碍标准的人数显著更多（71%）。接触组中最常见的诊断属于焦虑和情绪类别，有高比例（36%）的接触组受试者符合心境障碍和焦虑障碍双重诊断标准。两组在既往精神障碍、当前或既往物质滥用或依赖方面无差异。
有溶剂接触史的受试者中既往精神障碍的发生率与正常对照受试者相似，但接触组受试者中当前DSM-IV轴I精神障碍的患病率显著高于对照组受试者。
