Morrow L A, Stein L, Bagovich G R, Condray R, Scott A
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Appl Neuropsychol. 2001;8(2):65-73. doi: 10.1207/S15324826AN0802_1.
This study assessed neuropsychological performance in persons with a history of exposure to organic solvents and nonexposed healthy controls. Structured clinical interviews were also done to determine current Axis I diagnosis of mood disorder to assess the contribution of mood disorder to neuropsychological performance. Solvent-exposed participants were found to have significantly reduced scores on 3 of 5 neuropsychological clusters (learning and memory, visuospatial, psychomotor speed) compared to controls. No differences were found between the groups on measures of general intelligence. Within the exposed group, 50% met current Axis I criteria for mood disorder. Hierarchical multiple regression, controlling for age and education, revealed that mood disorder was significantly related to performance on only the visuospatial domain. There was no association between mood disorder and measures of learning and memory, attention, motor speed, and general intelligence. Higher ratings of past exposure were associated with poorer scores on learning and memory tests and slower times on speeded tests. These findings are consistent with other research documenting deficits in neuropsychological and psychiatric functioning in exposed workers.
本研究评估了有有机溶剂接触史的人群及未接触过有机溶剂的健康对照者的神经心理学表现。还进行了结构化临床访谈，以确定当前心境障碍的轴I诊断，从而评估心境障碍对神经心理学表现的影响。与对照组相比，接触溶剂的参与者在5个神经心理学类别中的3个（学习与记忆、视觉空间、心理运动速度）上的得分显著降低。两组在一般智力测量上未发现差异。在接触组中，50%符合当前心境障碍的轴I标准。在控制年龄和教育程度的情况下，分层多元回归显示，心境障碍仅与视觉空间领域的表现显著相关。心境障碍与学习与记忆、注意力、运动速度和一般智力的测量之间没有关联。过去接触程度的评分越高，学习与记忆测试的得分越低，速度测试的用时越长。这些发现与其他记录接触工人神经心理学和精神功能缺陷的研究一致。
