Ferrero V, Bussi M, Giordano L, Cavalot A L, Albera R
Dipartimento di Fisiopatologia Clinica, II Clinica di Otorinolaringoiatria, Università di Torino.
Acta Otorhinolaryngol Ital. 2000 Jun;20(3):159-64.
Ossicular chain defects modifying sound transmission through the middle ear can be treated with (re)implantation of remodeled autologous o homologous ossicles. In recent years, thanks to improved biocompatibility of the materials on the market, prostheses have been increasingly used in the partial or total ossicular chain reconstruction. The present study evaluates auditory ossicle reconstruction as a result of partial or total atrophy of the incus, comparing the use of the remodeled autologous incus with the use of partial hydroxyapatite prostheses (PORP). The study involved 79 patients of which 59 (74.7%) underwent ossicular chain reconstruction using a remodeled, inverted autologous incus while in the remaining 20 cases (25.3%) a hydroxyapatite prosthesis (PORP) was used. The effectiveness of the ossicular chain was evaluated by comparing pre- and postoperative audiometry and evaluating the average thresholds at frequencies of 0.5, 1, 2 and 3 KHz. The average preoperative audiometric gap (understood as the relationship between the air-bone gap) was 23 dB (Standard Deviation 11.2) while postoperatively it was 11 dB (SD 8.5) (p < 0.0001). Therefore the improvement in the air-bone gap was 12 dB (SD 11) for the overall population: 13 dB (SD 10) in those cases where reconstruction was performed using a remodeled incus and 8 dB (SD 11) when PORP was used. The postoperative cumulative gap between the air and bone pathways fell between 0 and 20 dB in 84% of the total population: 89% of those reconstructed with a remodeled incus and 73% of those using PORP. The middle ear ossicular chain reconstruction was performed using remodeled, inverted autologous incus in those cases where ossicular damage did not compromise its use while prostheses made of a biocompatible material (hydroxyapatite PORP) were reserved for those cases where the incus was absent or severely worn. The results obtained are satisfactory, remained stable in time and reflect the average values reported in the Literature.
通过(重新)植入重塑的自体或同种异体听小骨,可以治疗改变声音通过中耳传播的听骨链缺陷。近年来,由于市场上材料的生物相容性得到改善,假体越来越多地用于部分或全听骨链重建。本研究评估了因砧骨部分或完全萎缩导致的听骨重建情况,比较了使用重塑的自体砧骨与部分羟基磷灰石假体(PORP)的效果。该研究纳入了79例患者,其中59例(74.7%)使用重塑的倒置自体砧骨进行听骨链重建,其余20例(25.3%)使用羟基磷灰石假体(PORP)。通过比较术前和术后听力测定结果,并评估0.5、1、2和3kHz频率下的平均阈值,来评估听骨链的有效性。术前平均听力测定差距(理解为气骨差距之间的关系)为23dB(标准差11.2),术后为11dB(标准差8.5)(p<0.0001)。因此,总体人群中气骨差距的改善为12dB(标准差11):使用重塑砧骨进行重建的病例中为13dB(标准差10),使用PORP时为8dB(标准差11)。在84%的总体人群中,术后气骨通路之间的累积差距在0至20dB之间:使用重塑砧骨重建的患者中为89%,使用PORP的患者中为73%。在听骨损伤不影响其使用的情况下,使用重塑的倒置自体砧骨进行中耳听骨链重建,而由生物相容性材料(羟基磷灰石PORP)制成的假体则保留用于砧骨缺失或严重磨损的病例。所获得的结果令人满意,随时间保持稳定,并反映了文献中报道的平均值。