钙拮抗剂对偏头痛患者血小板中血清素依赖性聚集及血清素转运的影响。
Effects of calcium antagonists on serotonin-dependent aggregation and serotonin transport in platelets of patients with migraine.
作者信息
Pukhal'skaya T G, Kolosova O A, Men'shikov M Y, Vein A M
机构信息
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2000 Jul;130(7):633-5. doi: 10.1007/BF02682090.
Flunarizine and cinnarizine (IC50 6.8x10(-6) and 2.8x10(-5) M, respectively) inhibited 3H-serotonin uptake by platelets. In higher doses, they blocked serotonin-induced platelet aggregation and stimulated 3H-serotonin release from these cells. Imipramine did not affect serotonin-releasing effects of preparations. In all patients cinnarizine was more potent in inhibiting serotonin uptake, and in half of the patients cinnarizine displayed higher activity as an inductor of serotonin release.
氟桂利嗪和桂利嗪（IC50分别为6.8×10⁻⁶和2.8×10⁻⁵M）抑制血小板对³H - 血清素的摄取。在更高剂量时，它们阻断血清素诱导的血小板聚集，并刺激这些细胞释放³H - 血清素。丙咪嗪不影响制剂的血清素释放作用。在所有患者中，桂利嗪在抑制血清素摄取方面更有效，并且在一半的患者中，桂利嗪作为血清素释放诱导剂表现出更高的活性。
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