Cortelli P, Santucci M, Righetti F, Pirazzoli P, Cacciari E, Albani F, Baldrati A, De Carolis P, Baruzzi A, Sacquegna T
Cephalalgia. 1985 May;5 Suppl 2:185-6. doi: 10.1177/03331024850050S236.
The effect of 30-days of flunarizine (5 mg/day) therapy on pituitary, B-pancreatic, gonadic and adrenal function was studied in five adolescents with common migraine. Baseline concentration of growth hormone was significantly reduced after flunarizine therapy. The response of prolactin to thyrotrophin-releasing hormone was significantly increased after flunarizine therapy. The percentages of HbA1 and HbA1c were significantly higher after flunarizine therapy. The drug had no apparent effect on gonadic and adrenal function. Further studies are needed to confirm the effect of flunarizine on the hypothalamus-pituitary axis and glucose tolerance.
在五名患有普通偏头痛的青少年中，研究了为期30天的氟桂利嗪（5毫克/天）治疗对垂体、β胰腺、性腺和肾上腺功能的影响。氟桂利嗪治疗后生长激素的基线浓度显著降低。氟桂利嗪治疗后催乳素对促甲状腺激素释放激素的反应显著增加。氟桂利嗪治疗后糖化血红蛋白（HbA1）和糖化血红蛋白A1c（HbA1c）的百分比显著升高。该药物对性腺和肾上腺功能无明显影响。需要进一步研究以证实氟桂利嗪对下丘脑-垂体轴和葡萄糖耐量的影响。
