Fanciullacci M, Boccuni M, Pietrini U, Cangi F, Gatto G, Marabini S, Fusco B M
Cephalalgia. 1985 May;5 Suppl 2:181-3. doi: 10.1177/03331024850050S235.
In migraine patients the effect of calcium antagonists (flunarizine, verapamil and nifedipine) on both venous and pupillary neuromuscular functions, as well as on blood pressure have been evaluated. A single oral dose of flunarizine (10 mg) and verapamil infusion (50 micrograms/ml/min) increased venous compliance. Verapamil also counteracted dose-dependent dopamine induced venoconstriction. Nifedipine (10 mg orally) reduced mean arterial pressure in upright position in migraineurs but not in controls. In addition, chronic treatment with flunarizine (10 mg for 2 weeks) induced a transient miotic effect and a reduction of tyramine induced mydriasis. These findings demonstrated that calcium antagonists affect vascular and extravascular structures. It is postulated that, in migraine, calcium entry blockers may prevent exaggerated responses to catecholaminergic stimulation.
在偏头痛患者中，已评估了钙拮抗剂（氟桂利嗪、维拉帕米和硝苯地平）对静脉和瞳孔神经肌肉功能以及血压的影响。单次口服氟桂利嗪（10毫克）和静脉输注维拉帕米（50微克/毫升/分钟）可增加静脉顺应性。维拉帕米还可抵消多巴胺诱导的剂量依赖性静脉收缩。硝苯地平（口服10毫克）可降低偏头痛患者直立位时的平均动脉压，但对对照组无此作用。此外，长期使用氟桂利嗪（10毫克，持续2周）可产生短暂的缩瞳作用，并减少酪胺诱导的散瞳。这些发现表明钙拮抗剂会影响血管和血管外结构。据推测，在偏头痛中，钙通道阻滞剂可能会预防对儿茶酚胺能刺激的过度反应。
