血管紧张素II对新生白化大鼠气管支气管系统上皮细胞和平滑肌细胞增殖活性的影响
Effects of angiotensin II on proliferative activity of epitheliocytes and smooth muscle cells of the tracheobronchial system in newborn albino rats.
作者信息
Lebed'ko O A, Timoshin S S, Bespalova N N
机构信息
Institute of Maternity and Child Welfare, Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk.
出版信息
Bull Exp Biol Med. 2000 Jul;130(7):636-8. doi: 10.1007/BF02682091.
Angiotensin II was injected intraperitoneally in a dose of 5x10(-8) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with 3H-thymidine showed that angiotensin II stimulated DNA synthesis in epitheliocytes and smooth muscle cells of the trachea and large (cartilaginous) and small (noncartilaginous) bronchi, intensified lipid peroxidation, and activated the antioxidant defense system in the lungs.
在新生大鼠出生后第2至6天，以5×10⁻⁸摩尔/千克的剂量腹腔注射血管紧张素II。用³H-胸腺嘧啶进行放射自显影显示，血管紧张素II刺激气管、大（软骨性）支气管和小（非软骨性）支气管的上皮细胞和平滑肌细胞中的DNA合成，增强脂质过氧化，并激活肺中的抗氧化防御系统。
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