九头蛇肽形态发生素及其类似物和片段对新生白化大鼠气管上皮和平滑肌细胞DNA合成的影响。
Effects of hydra peptide morphogen and its analogue and fragments on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats.
作者信息
Lebed'ko O A, Timoshin S S, Rubina A Y
机构信息
Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2000 Jun;129(6):550-2. doi: 10.1007/BF02434873.
Hydra peptide morphogen, its Arg(7) analogue, and 6C, 3C, and 5N fragments were injected intraperitoneally in a dose 10(-7) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with (3)H-thymidine showed that hydra peptide morphogen and its 6C fragment stimulated DNA synthesis in tracheal epitheliocytes, but inhibited this process in smooth muscle cells. 5N fragment inhibited DNA synthesis in both tissues, while 3C and Arg(7) were ineffective.
将水螅肽形态发生原、其精氨酸（7）类似物以及6C、3C和5N片段以10⁻⁷摩尔/千克的剂量在新生大鼠出生后第2天至第6天经腹腔注射。用³H-胸腺嘧啶进行放射自显影显示，水螅肽形态发生原及其6C片段刺激气管上皮细胞中的DNA合成，但在平滑肌细胞中抑制这一过程。5N片段在两种组织中均抑制DNA合成，而3C和精氨酸（7）则无作用。
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