Utsunomiya Y, Kado T, Koda T, Okada S, Hayashi A, Fukawaza A, Nakagawa T, Kanzaki S, Kasagi T
Department of Pediatrics, Faculty of Medicine, Tottori University, Yonago, Japan.
Clin Nephrol. 2000 Dec;54(6):443-8.
The aim of this study is to clarify the age-related characteristics of pediatric IgA nephropathy.
Five cases in preschool children less than 6 years old were analyzed and compared to 38 cases in older children from 6 to 15 years old.
The group of younger children had higher incidences of gross hematuria, hypertension, proteinuria, and hypoproteinemia. Renal biopsy specimens in this group showed more intracapillary lesions including mesangial cell proliferation and endocapillary proliferation ofglomeruli, but less segmental lesions, global sclerosis, and interstitial changes.
IgA nephritis in preschool children demonstrated more symptoms of acute onset and less chronic renal injury.
本研究旨在阐明儿童IgA肾病的年龄相关特征。
分析了5例6岁以下学龄前儿童的病例，并与38例6至15岁大龄儿童的病例进行比较。
年龄较小儿童组肉眼血尿、高血压、蛋白尿和低蛋白血症的发生率较高。该组肾活检标本显示更多的毛细血管内病变，包括系膜细胞增生和肾小球毛细血管内增生，但节段性病变、球性硬化和间质改变较少。
学龄前儿童的IgA肾炎表现出更多急性起病症状和更少的慢性肾损伤。
