Hardell L, Breivald M, Hennerdal S, Fernberg J O, Strander H
Department of Oncology, Orebro Medical Center, Sweden.
Cytokines Cell Mol Ther. 2000 Sep;6(3):155-6. doi: 10.1080/mccm.6.3.155.156.
We report on a case with desmoid tumor sucessfully treated with low-dose interferon alfa. A desmoid tumor was diagnosed in August 1998 in the right shoulder area of a 23-year-old woman. Surgery would probably have permanently impaired muscle function in her shoulder and arm. Therefore, interferon alfa treatment (0.9 million units twice daily subcutaneously) was started in November 1998 (time = 0). The tumor volume based on magnetic resonance imaging (MRI) was initially 16 cm3. The size of the tumor decreased gradually during 12 months of treatment, and in November 1999 (time = 12 months) MRI showed no clear tumor demarcation. This treatment modality may be considered as an alternative to mutilating surgery in patients with desmoid tumor.
我们报告了一例经低剂量干扰素α成功治疗的韧带样瘤病例。1998年8月，一名23岁女性的右肩部被诊断出患有韧带样瘤。手术可能会永久性损害她肩部和手臂的肌肉功能。因此，1998年11月（时间=0）开始进行干扰素α治疗（皮下注射，每日两次，每次90万单位）。基于磁共振成像（MRI）的肿瘤体积最初为16立方厘米。在治疗的12个月期间，肿瘤大小逐渐减小，1999年11月（时间=12个月）MRI显示肿瘤无明显边界。对于韧带样瘤患者，这种治疗方式可被视为一种替代致残性手术的选择。
