Samorì B
Dipartimento di Biochimica, Università di Bologna, Italy.
Chemistry. 2000 Dec 1;6(23):4249-55. doi: 10.1002/1521-3765(20001201)6:23<4249::aid-chem4249>3.3.co;2-p.
Individual molecules can be stretched with a scanning force microscope and the forces required to rupture bonds and to mechanically drive their structures towards new conformations and states can be measured. The tailoring of the experiments, the possibility of carrying them out in quasi-equilibrium conditions, the relationships between single molecule force measurements, and macroscopic kinetics or thermodynamic data are discussed. Mechanochemical experiments are expanding chemistry into new realms between biology and material science.
可以用扫描力显微镜拉伸单个分子，并测量断裂化学键以及将其结构机械驱动至新构象和状态所需的力。本文讨论了实验的定制、在准平衡条件下进行实验的可能性、单分子力测量与宏观动力学或热力学数据之间的关系。机械化学实验正在将化学扩展到生物学和材料科学之间的新领域。
