Sakuno E, Yabe K, Hamasaki T, Nakajima H
Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Koyama, Tottori 680-8553, Japan.
J Nat Prod. 2000 Dec;63(12):1677-8. doi: 10.1021/np000194w.
Screening for inhibitors of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, resulted in the isolation of a new metabolite (1) from Trichoderma hamatum. On the basis of spectroscopic data, 1 was determined to be 4, 6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano[7, 6-e]cyclopenta[c]2H-pyran-1,9-dione.
对5'-羟基averantin脱氢酶（一种参与黄曲霉毒素生物合成的酶）的抑制剂进行筛选，结果从哈茨木霉中分离出一种新的代谢产物（1）。根据光谱数据，确定1为4,6-二羟基-5-甲氧基-6a-甲基环六[德]茚并[7,6-e]环戊[c]2H-吡喃-1,9-二酮。
