Périssé A R, Schechter M, Moreira R I, do Lago R F, Santoro-Lopes G, Harrison L H
Infectious Diseases Service, Hospital Universitário Clementino Fraga Filho, Brazil.
J Acquir Immune Defic Syndr. 2000 Dec 15;25(5):459-63. doi: 10.1097/00126334-200012150-00012.
Evaluation of HIV vaccines requires high-risk individuals willing to participate in a vaccine trial. We investigated the willingness to participate in HIV vaccine trials of initially HIV-seronegative homosexual men enrolled in an HIV seroincidence cohort study. Of 815 initially HIV-seronegative participants, 569 (69.8%) reported willingness to participate in an HIV vaccine trial. Altruism was the primary reason given for wanting to participate. Fear of HIV infection from the study's immunizations and a vaccine-induced positive HIV test result were the main reasons for not wanting to participate. Of the 34 study subjects who eventually had HIV seroconversion, 29 (85%) had indicated a willingness to participate. In a univariate analysis, factors associated with willingness to participate included HIV seroconversion during follow-up (odds ratio [OR]. 2.6; p =.04), low educational level (OR, 1.6; p =.005), low family income (p =.02), and exchanging sex for housing, food, or clothing (OR 6.1; p =.005). Students were less likely to be willing to participate in a trial (OR, 0.7; p = .03), as well as those who reported sex at the first encounter (OR, 0.7; p = .05). In a multivariate analysis, low education level, infection with Condyloma, and exchanging sex for housing, food, or clothing were positively associated with willingness to participate, whereas being a student and reporting sex at first encounter were negatively associated. In general, factors indicative of high-risk of HIV infection were associated with a higher willingness. These data demonstrate that this high-risk homosexual male cohort has a high willingness to participate in HIV vaccine trials.
评估HIV疫苗需要有愿意参与疫苗试验的高危个体。我们调查了参加HIV血清阳转队列研究的初始HIV血清阴性同性恋男性参与HIV疫苗试验的意愿。在815名初始HIV血清阴性参与者中，569名（69.8%）表示愿意参与HIV疫苗试验。利他主义是表示愿意参与的主要原因。担心因研究中的免疫接种感染HIV以及疫苗导致HIV检测结果呈阳性是不愿意参与的主要原因。在最终发生HIV血清阳转的34名研究对象中，29名（85%）曾表示愿意参与。单因素分析显示，与参与意愿相关的因素包括随访期间HIV血清阳转（比值比[OR]为2.6；P = 0.04）、低教育水平（OR为1.6；P = 0.005）、低家庭收入（P = 0.02）以及以性交换住房、食物或衣物（OR为6.1；P = 0.005）。学生参与试验的可能性较小（OR为0.7；P = 0.03），首次性行为时即有性行为的人也是如此（OR为0.7；P = 0.05）。多因素分析显示，低教育水平、感染尖锐湿疣以及以性交换住房、食物或衣物与参与意愿呈正相关，而身为学生和首次性行为时即有性行为与参与意愿呈负相关。总体而言，表明HIV感染高危的因素与更高的参与意愿相关。这些数据表明，这一高危同性恋男性队列参与HIV疫苗试验的意愿较高。
