Duchek P, Rørth P
Developmental Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Science. 2001 Jan 5;291(5501):131-3. doi: 10.1126/science.291.5501.131.
Directed cell migration is important for many aspects of normal animal development, but little is known about how cell migrations are guided or the mechanisms by which guidance cues are translated into directed cell movement. Here we present evidence that signaling mediated by the epidermal growth factor receptor (EGFR) guides dorsal migration of border cells during Drosophila oogenesis. The transforming growth factor-alpha (TGF-alpha)-like ligand Gurken appears to serve as the guidance cue. To mediate this guidance function, EGFR signals via a pathway that is independent of Raf-MAP kinase and receptor-specific.
定向细胞迁移对正常动物发育的许多方面都很重要，但对于细胞迁移如何被引导以及引导信号如何转化为定向细胞运动的机制却知之甚少。在此，我们提供证据表明，表皮生长因子受体（EGFR）介导的信号传导在果蝇卵子发生过程中引导边界细胞的背侧迁移。转化生长因子-α（TGF-α）样配体 Gurken 似乎充当了引导信号。为了介导这种引导功能，EGFR 通过一条独立于 Raf-MAP 激酶且具有受体特异性的途径发出信号。
