Belianchikova N I, Veskova T K, Chimishkian K L, Trubcheninova L P, Svet-Moldavskiĭ G Ia
Vopr Onkol. 1979;25(6):76-80.
Changes in the absolute number of splenic cells of mice infected with Rauscher leukemia virus (RLV) and a day later--with living Brucella (BA) were studied. The increase in the absolute number of splenic cells of mice infected with RLV + BA was initially caused by the lymphoid tissue reaction to Brycella and then by the development of leukemia. The number of reticular cells in the spleen appeared to be larger than the control (RLV) within all observation periods; the number of basophilic normocytes amounted to the control, but an increase in the erythroblasts number was noted a week later and reached the control level by the 30th day, practically being unchanged subsequently. In mice receiving RLV + BA there was the increased monocyte, plasmatic cell, megakaryocyte, myeloid series cell count. The shift of splenic granulocytes to the "left", the development of leukocytosis, blood neutrophilia, in particular, lagged 1--2 weeks behind in such mice. The number of normocytes getting into the blood was decreased. All this would result in a significant extension of the lifespan in mice RLV + BA.
研究了感染劳斯氏白血病病毒（RLV）的小鼠以及一天后感染活布鲁氏菌（BA）的小鼠脾脏细胞绝对数量的变化。感染RLV + BA的小鼠脾脏细胞绝对数量增加，最初是由于淋巴组织对布鲁氏菌的反应，随后是白血病的发展。在所有观察期内，脾脏中网状细胞的数量似乎比对照组（RLV）多；嗜碱性正常血细胞的数量与对照组相当，但一周后成红细胞数量增加，并在第30天达到对照水平，随后基本保持不变。接受RLV + BA的小鼠单核细胞、浆细胞、巨核细胞、髓系细胞数量增加。此类小鼠脾脏粒细胞向“左”移、白细胞增多症尤其是血液嗜中性粒细胞增多症的发展滞后1至2周。进入血液的正常血细胞数量减少。所有这些都会导致RLV + BA小鼠的寿命显著延长。
