Suppr超能文献

体型与前列腺癌:一项基于中国人群的病例对照研究。

Body size and prostate cancer: a population-based case-control study in China.

作者信息

Hsing A W, Deng J, Sesterhenn I A, Mostofi F K, Stanczyk F Z, Benichou J, Xie T, Gao Y T

机构信息

Division of Cancer Epidemiology and Genetics, National Cancer Institute. Bethesda, Maryland 20852-7234, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1335-41.

Abstract

We conducted a population-based case-control study in China to investigate whether body size plays a role in prostate cancer etiology and whether it can explain the rapid increase in prostate cancer incidence rates in China. A total of 238 cases newly diagnosed with primary prostate cancer in Shanghai, China, during 1993-1995 were included in the study. Four hundred and seventy-one healthy control subjects were randomly selected from among residents of Shanghai and frequency-matched to cases on the basis of age. In-person interviews were conducted to elicit information on height, weight history, and other lifestyle factors. Waist and hip circumferences were measured at interview. Odds ratios (ORs) were used to measure the association between prostate cancer and anthropometric variables including height, weight, body mass index (BMI), waist, hip, and right upper arm circumferences, and waist-to-hip ratio (WHR; an indicator of abdominal adiposity). High levels of WHR were related to an excess risk, with men in the highest quartile (WHR > 0.92) having an almost 3-fold risk (OR, 2.71; 95% CI = 1.66-4.41; Ptrend = 0.0001) compared with men in the lowest quartile (WHR < 0.86). In contrast, men in the highest quartile of hip circumference (>97.4 cm) had a reduced risk (OR, 0.46; 95% CI = 0.29-0.74; Ptrend = 0.0002) relative to men in the lowest quartile (<86 cm). No association was found for height, usual adult weight, or preadult and usual adult BMI. Our results suggest that even in a very lean population (average BMI = 21.9), abdominal adiposity may be associated with an increased risk of clinical prostate cancer, pointing to a role of hormones in prostate cancer etiology. Additional research is needed to confirm these findings in prospective studies, especially in Western populations where abdominal obesity is much more common, and to clarify the underlying hormonal mechanisms involved.

摘要

我们在中国开展了一项基于人群的病例对照研究,以调查体型是否在前列腺癌病因中起作用,以及它能否解释中国前列腺癌发病率的快速上升。该研究纳入了1993年至1995年期间在中国上海新诊断出的238例原发性前列腺癌病例。从上海居民中随机选取了471名健康对照者,并根据年龄与病例进行频数匹配。通过面对面访谈获取身高、体重史及其他生活方式因素的信息。在访谈时测量腰围和臀围。采用比值比(OR)来衡量前列腺癌与人体测量学变量之间的关联,这些变量包括身高、体重、体重指数(BMI)、腰围、臀围、右上臂围以及腰臀比(WHR;腹部肥胖的一个指标)。高水平的WHR与额外风险相关,与最低四分位数(WHR<0.86)的男性相比,最高四分位数(WHR>0.92)的男性患癌风险几乎高出3倍(OR,2.71;95%可信区间=1.66 - 4.41;P趋势=0.0001)。相比之下,臀围最高四分位数(>97.4 cm)的男性相对于最低四分位数(<86 cm)的男性风险降低(OR,0.46;95%可信区间=0.29 - 0.74;P趋势=0.0002)。未发现身高、成年时通常体重或成年前及成年时BMI与前列腺癌存在关联。我们的研究结果表明,即使在很瘦的人群中(平均BMI = 21.9),腹部肥胖也可能与临床前列腺癌风险增加有关,这表明激素在前列腺癌病因中起作用。需要进一步的研究在前瞻性研究中证实这些发现,特别是在腹部肥胖更为常见的西方人群中,并阐明其中潜在的激素机制。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验