Lavalette Céline, Trétarre Brigitte, Rebillard Xavier, Lamy Pierre-Jean, Cénée Sylvie, Menegaux Florence
Université Paris-Saclay, Université Paris-Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment, Villejuif, France.
Registre des Tumeurs de l'Hérault, ICM, Montpellier, France.
Oncotarget. 2018 Oct 2;9(77):34485-34494. doi: 10.18632/oncotarget.26128.
Obesity is associated with an increased risk of several cancers, but inconsistent results have been observed between body mass index (BMI) and prostate cancer (PCa) risk. However, some associations have been reported with other indicators such as waist circumference (WC) and waist-hip ratio (WHR). We investigated the role of anthropometric indicators in PCa risk based on data from the Epidemiological study of Prostate Cancer (EPICAP). EPICAP is a population-based case-control study that included 819 incident PCa in 2012-2013 and 879 controls frequency matched by age. Anthropometric indicators (weight, height, WC, and hip circumference) have been measured at interview. Logistic regression models were used to assess odds ratios (ORs) for the associations between anthropometric indicators (BMI, WC and WHR) and PCa risk. We observed a slight, but not significant increased risk of PCa for men with a WC > 94 cm (OR 1.20, 95% CI 0.92-1.56) and for men with a WHR ≥ 0.95 (OR 1.30, 95% CI 1.00-1.70 between 0.95 and 1.00, OR 1.25, 95% CI 0.96-1.61 above 1.00). Associations were more pronounced after adjustment and stratification for BMI and in men with aggressive PCa. Our results suggest that abdominal obesity may be associated with an increased risk of PCa, especially aggressive PCa.
肥胖与多种癌症风险增加相关，但体重指数（BMI）与前列腺癌（PCa）风险之间的研究结果并不一致。然而，已有报道称其他指标如腰围（WC）和腰臀比（WHR）与前列腺癌存在一些关联。我们基于前列腺癌流行病学研究（EPICAP）的数据，调查了人体测量指标在前列腺癌风险中的作用。EPICAP是一项基于人群的病例对照研究，在2012 - 2013年纳入了819例新发前列腺癌病例和879例年龄频率匹配的对照。在访谈时测量了人体测量指标（体重、身高、腰围和臀围）。使用逻辑回归模型评估人体测量指标（BMI、WC和WHR）与前列腺癌风险之间关联的优势比（OR）。我们观察到，腰围>94 cm的男性患前列腺癌的风险略有增加，但不显著（OR 1.20，95%CI 0.92 - 1.56），腰臀比≥0.95的男性患前列腺癌的风险增加（0.95至1.00之间，OR 1.30，95%CI 1.00 - 1.70；高于1.00时，OR 1.25，95%CI 0.96 - 1.61）。在对BMI进行调整和分层后以及在侵袭性前列腺癌男性中，这种关联更为明显。我们的结果表明，腹部肥胖可能与前列腺癌风险增加相关，尤其是侵袭性前列腺癌。
