婴幼儿及儿童良性短暂性高磷酸酶血症

Benign transient hyperphosphatasemia of infancy and childhood.

作者信息

Tolaymat N, de Melo M C

机构信息

Department of Pediatrics, Robert C. Byrd Health Science Center of West Virginia University, Charleston, USA.

出版信息

South Med J. 2000 Dec;93(12):1162-4.

PMID:11142449

Abstract

Six children, aged 11 to 25 months, were found to have elevated serum alkaline phosphatase (ALP) levels (1,077 to 9,271 U/L) in the absence of disease. Benign transient hyperphosphatasemia (BTH) was diagnosed when the serum ALP levels returned to normal or decreased significantly within 3 months. Several theories have been suggested regarding the pathophysiology of BTH, but the exact cause is still unclear. We report six cases of BTH and review the literature. It is important to recognize this condition and to avoid extensive and unnecessary evaluation.

摘要

6名年龄在11至25个月的儿童在未患疾病的情况下被发现血清碱性磷酸酶（ALP）水平升高（1077至9271 U/L）。当血清ALP水平在3个月内恢复正常或显著下降时，诊断为良性暂时性高磷酸酶血症（BTH）。关于BTH的病理生理学已提出几种理论，但确切病因仍不清楚。我们报告6例BTH并复习文献。认识到这种情况并避免进行广泛且不必要的评估很重要。