Schneider A M, Koven N S, Lombardo K A, Levin D A, Simson P E
Department of Psychology, Swarthmore College, Pennsylvania 19081, USA.
Behav Neurosci. 2000 Dec;114(6):1256-60.
The effect of beta-adrenergic receptor blockade on retention in a mildly aversive passive-avoidance procedure was investigated. Rats were given passive-avoidance training--1 trial per day for 4 days-and were administered saline, the centrally and peripherally acting beta-adrenergic blocker propranolol (4 or 10 mg/kg ip), or the peripherally acting beta-adrenergic blocker sotalol (4 or 10 mg/kg ip) immediately or 2 hr after the 1st trial. Enhanced retention occurred only with the higher dose (10 mg/kg) of propranolol and only when it was administered immediately after training. The enhanced retention produced by propranolol is discussed in terms of opposing, regionally specific actions of beta-adrenergic receptor-mediated neural circuits on modulation of memory.
研究了β-肾上腺素能受体阻断对轻度厌恶被动回避程序中记忆保持的影响。大鼠接受被动回避训练——每天1次，共4天——并在首次训练后立即或2小时给予生理盐水、中枢和外周作用的β-肾上腺素能阻滞剂普萘洛尔（4或10mg/kg腹腔注射）或外周作用的β-肾上腺素能阻滞剂索他洛尔（4或10mg/kg腹腔注射）。仅在给予较高剂量（10mg/kg）的普萘洛尔且仅在训练后立即给药时，记忆保持增强。根据β-肾上腺素能受体介导的神经回路对记忆调节的相反、区域特异性作用，讨论了普萘洛尔产生的记忆保持增强作用。
