Meng X H, Zhu K Y, Krishnan S M, Tan Y S
School of Electronic and Electrical Engineering, Nanyang Technological University, Singapore 639798.
Biomed Sci Instrum. 1999;35:129-34.
In this paper, adaptive control systems have been developed for the closed-loop control of mean arterial pressure using vasoactive drugs. An adaptive algorithm based on generalized predictive control law has been presented. A adaptive PI controller has been designed. The recursive least-square identification algorithm is used for on-line parameter estimation. The supervisor is added to provide safety and efficacy of control under the consideration of the physical and physiological constraints. Extensive computer simulation in the presence of unpredictable disturbances shows the system is capable of inducing hypertension.
本文针对使用血管活性药物对平均动脉压进行闭环控制开发了自适应控制系统。提出了一种基于广义预测控制律的自适应算法。设计了一种自适应PI控制器。采用递推最小二乘辨识算法进行在线参数估计。加入监控器以在考虑物理和生理约束的情况下确保控制的安全性和有效性。在存在不可预测干扰的情况下进行的大量计算机仿真表明该系统能够诱发高血压。
