Behbehani K, Cross R R
Department of Biomedical Engineering, University of Texas, Arlington 76019.
IEEE Trans Biomed Eng. 1991 Jun;38(6):513-21. doi: 10.1109/10.81575.
Automation of drug delivery for control of mean arterial blood pressure is highly desirable in a number of clinical applications. An integrating self-tuning control strategy for control of mean arterial blood pressure using sodium nitroprusside is presented. Next to robust performance, the most attractive feature of the controller is its capability to optimize the quantity of infused medication without introducing a bias in the blood pressure level; a problem that existed in some of the other adaptive control strategies that have been proposed previously. Further, the controller design requires only the knowledge of the pure delay and the order of the transfer function describing the patient's response to the medication; it does not require that the entire transfer function be specified. The derivation of the controller is not based on the patient response to sodium nitroprusside; indeed, it is a general adaptive control strategy for control of systems with transport delay. The controller performs robustly in the presence of variations in the patient response and successfully controls the pressure at the desired level. The ability of this strategy to reduce the amount of infused medication makes it potentially attractive for use in clinical applications, as large doses or long term use of sodium nitroprusside can adversely affect central nervous system and hematopoietic tissues.
在许多临床应用中，实现用于控制平均动脉血压的药物输送自动化是非常可取的。本文提出了一种使用硝普钠控制平均动脉血压的积分自整定控制策略。除了具有强大的性能外，该控制器最吸引人的特点是它能够优化输注药物的量，而不会在血压水平上引入偏差；这是先前提出的一些其他自适应控制策略中存在的问题。此外，控制器设计仅需要了解纯延迟以及描述患者对药物反应的传递函数的阶数；不需要指定整个传递函数。控制器的推导并非基于患者对硝普钠的反应；实际上，它是一种用于控制具有传输延迟系统的通用自适应控制策略。该控制器在患者反应存在变化的情况下仍能稳健运行，并成功将压力控制在所需水平。这种策略减少输注药物量的能力使其在临床应用中具有潜在的吸引力，因为大剂量或长期使用硝普钠会对中枢神经系统和造血组织产生不利影响。
