Dhaware B S, Balsara J J, Nandal N V, Chandorkar A G
Department of Pharmacology, Padmashree Dr. DY Patil Medical College for Women, Pimpri, Pune 411018.
Indian J Med Sci. 2000 Aug;54(8):321-4.
Amantadine, a dopamine agonist is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine dependent-behaviors are reversed by amantadine. Amantadine has also revered molindone-induced inhibition of traction response in mice. Our study indicates that amantadine, like other DA agonists, e.g. amphetamine and apomorphine can antagonize or even reverse the neuroleptic induced dopaminergic behaviors.
金刚烷胺是一种多巴胺激动剂，据报道它作为一种抗帕金森病药物，通过从多巴胺能神经末梢释放多巴胺来发挥作用。在目前对大鼠的行为学研究中，吗茚酮诱导的僵住症和眼睑下垂（这两种行为依赖多巴胺）可被金刚烷胺逆转。金刚烷胺还能逆转吗茚酮对小鼠牵张反应的抑制作用。我们的研究表明，金刚烷胺与其他多巴胺激动剂（如苯丙胺和阿扑吗啡）一样，可以拮抗甚至逆转抗精神病药物诱导的多巴胺能行为。
