Armitage R
Sleep Study Unit, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9070, USA.
Can J Psychiatry. 2000 Nov;45(9):803-9. doi: 10.1177/070674370004500903.
This paper reviews sleep disturbances in patients with major depressive disorders and the effects of different classes of antidepressants on sleep. It is clear from the studies reviewed that not all antidepressants improve sleep, and, indeed, some worsen sleep disturbances in patients with depression. Whether sleep is improved or further disrupted is of high clinical significance, because persistent sleep problems elevate the risk of relapse, recurrence, or suicide, as well as the need for augmenting medications.
本文综述了重度抑郁症患者的睡眠障碍以及不同种类抗抑郁药对睡眠的影响。从所综述的研究中可以清楚地看出，并非所有抗抑郁药都能改善睡眠，实际上，有些抗抑郁药会加重抑郁症患者的睡眠障碍。睡眠是得到改善还是进一步受到干扰具有很高的临床意义，因为持续的睡眠问题会增加复发、再发或自杀的风险，以及增加辅助用药的必要性。
