Mohammed R A, Idris O A, el Sanousi S M, Abdelsalam E B
Department of Pathology, Faculty of Veterinary Science, University of Khartoum, Sudan.
Dtsch Tierarztl Wochenschr. 2000 Oct;107(10):414-6.
Enteric coccidiosis was experimentally induced in Nubian goat kids by the oral inoculation of 1.5 x 10(6) sporulated oocysts of five mixed Eimeria species. Diarrhoea was the major manifestation of the disease, which terminated fatally within 19 to 25 days postinfection. Faecal excretion of oocysts was first detected on day 8 (mean 58 x 10(2)) with a maximum shedding (mean 16.39 x 10(5)) on day 14 post-infection. In addition, noticeable alterations were further observed on the normal constituents of the gut microflora in coccidia-infected kids. These changes were characterized by progressive reduction of the Gram-positive population from 84% pre-infection to 24.3% after the onset of diarrhoea. On the other hand, the Gramnegative population was conversely increased from 16% pre-infection to 75.7% after diarrhoea. At this stage (diarrhoea) E. coli was the most dominant organism amongst the various constituents of the gut microflora.
通过口服接种1.5×10⁶个由五种艾美耳球虫混合而成的孢子化卵囊，在努比亚山羊幼崽中实验性诱发了肠道球虫病。腹泻是该病的主要表现，感染后19至25天内病情致命。感染后第8天首次检测到卵囊的粪便排泄（平均58×10²），感染后第14天排泄量最大（平均16.39×10⁵）。此外，在感染球虫的山羊幼崽中，还进一步观察到肠道微生物群正常成分的明显变化。这些变化的特征是革兰氏阳性菌数量从感染前的84%逐渐减少到腹泻开始后的24.3%。另一方面，革兰氏阴性菌数量则相反，从感染前的16%增加到腹泻后的75.7%。在这个阶段（腹泻期），大肠杆菌是肠道微生物群各种成分中最主要的微生物。
