Feany M B, Anthony D C, Frosch M P, Zane W, De Girolami U
Department of Pathology, Brigham and Women's Hospital and Children's Hospital, Boston, MA, USA.
Brain Pathol. 2001 Jan;11(1):121-2, 125.
The August COM: Acute methanol poisoning is an uncommon, but well-recognized, cause of central nervous system injury. We present two autopsy cases showing the classic neuropathologic injuries in acute methanol poisoning: putamen and white matter necrosis and hemorrhage. In Case 1, putamen hemorrhages were striking; white matter pathology predominated in Case 2. The precise mechanism of methanol toxicity is unclear. Direct toxicity of metabolites, particularly formic acid, as well as ischemic injury and acidosis likely play a role. Methanol is readily available in many commercial products, and may be ingested accidentally or intentionally.
8月通讯：急性甲醇中毒是中枢神经系统损伤的一种罕见但已被充分认识的病因。我们展示了两例尸检病例，显示了急性甲醇中毒典型的神经病理学损伤：壳核及白质坏死和出血。在病例1中，壳核出血明显；病例2中白质病变占主导。甲醇毒性的确切机制尚不清楚。代谢产物尤其是甲酸的直接毒性，以及缺血性损伤和酸中毒可能起了作用。甲醇在许多商业产品中很容易获得，可能会被意外或故意摄入。
