Monti J M, Alvariño F, Monti D
Department of Pharmacology and Therapeutics, Clinics Hospital, Montevideo, Uruguay.
Sleep. 2000 Dec 15;23(8):1075-84.
The purpose of this study was 1) to assess the effect of zolpidem or a placebo on sleep in two groups of insomniac patients with a diagnosis of moderate-to-severe chronic primary insomnia and 2) to determine the effect of zolpidem on sleep structure using spectral analysis.
A randomized, double-blind, placebo-controlled trial.
Sleep laboratory of the Department of Pharmacology and Therapeutics at the Clinics Hospital.
12 female outpatients with chronic primary insomnia.
Zolpidem was given at a daily dose of 10 mg for 15 nights.
The hypnotic drug reduced sleep latency and waking time after sleep onset, and increased total sleep time and sleep efficiency. Values corresponding to visually scored slow wave sleep (stage 3 and 4) showed no significant changes. All-night spectral analysis of the EEG revealed that power density in NREM sleep was significantly increased in the low frequency band (0.25-1.0 Hz) in the zolpidem group during the first 2-h interval.
In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. Moreover, zolpidem increased power density in the 0.25-1.0 Hz band during short-term and intermediate-term treatment. Nevertheless, other frequency bands in the delta range showed a relative decrease which was not statistically significant.
本研究的目的是1）评估唑吡坦或安慰剂对两组诊断为中度至重度慢性原发性失眠的失眠患者睡眠的影响，以及2）使用频谱分析确定唑吡坦对睡眠结构的影响。
一项随机、双盲、安慰剂对照试验。
临床医院药理学与治疗学系睡眠实验室。
12名患有慢性原发性失眠的女性门诊患者。
唑吡坦以每日10毫克的剂量给药，持续15个晚上。
催眠药物缩短了入睡潜伏期和睡眠开始后的清醒时间，并增加了总睡眠时间和睡眠效率。与视觉评分的慢波睡眠（3期和4期）相对应的值没有显著变化。脑电图的全夜频谱分析显示，唑吡坦组在最初2小时内非快速眼动睡眠中的低频带（0.25 - 1.0赫兹）功率密度显著增加。
与先前在慢性原发性失眠患者中获得的结果一致，唑吡坦显著改善了睡眠诱导和维持。此外，唑吡坦在短期和中期治疗期间增加了0.25 - 1.0赫兹频段的功率密度。然而，δ范围内的其他频段显示出相对下降，但无统计学意义。
