Coomber B L, Nyarko K A, Noyes T M, Gentry P A
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
Vet J. 2001 Jan;161(1):41-62. doi: 10.1053/tvjl.2000.0516.
Respiratory disease is a serious and significant health problem for the bovine industry. Classically, the clinical and research focus has been on the putative causative agents and conditions, and their interactions with host inflammatory cells, particularly alveolar macrophages and blood neutrophils. There is, currently, growing acceptance of the concept that blood platelets play a primary role in the inflammatory process. This review explores the implications of such pro-inflammatory activity, especially in the context of neutrophil-platelet interactions, and the species specificity of cellular responses. The relevance of these issues for the treatment and prevention of bovine respiratory disease is also discussed.
呼吸道疾病对养牛业来说是一个严重且重大的健康问题。传统上，临床和研究的重点一直放在假定的病原体和病症，以及它们与宿主炎症细胞，特别是肺泡巨噬细胞和血液中性粒细胞的相互作用上。目前，越来越多的人接受这样一种观念，即血小板在炎症过程中起主要作用。这篇综述探讨了这种促炎活性的影响，特别是在中性粒细胞与血小板相互作用的背景下，以及细胞反应的物种特异性。还讨论了这些问题对牛呼吸道疾病治疗和预防的相关性。
