Shimizu S, Chen K R, Tagami H, Hanabusa H
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Dermatology. 2000;201(4):321-5. doi: 10.1159/000051546.
Although various mucocutaneous manifestations have been reported in patients infected with HIV by sexual transmission or intravenous drug use, the prevalence and characteristics of skin disorders in HIV-positive hemophiliacs coinfected with hepatitis C virus (HCV) have rarely been described.
The purpose of this study was to clarify the characteristics of skin disorders in HIV-positive hemophiliacs and to identify differences in comparison with other HIV-positive groups.
A prospective study of the prevalence of mucocutaneous manifestations in 110 Japanese hemophiliacs (53 HIV-positive hemophiliacs including 24 AIDS and 57 HIV-negative hemophiliacs) was performed from July 1997 to July 1998.
None of the hemophiliacs developed Kaposi's sarcoma or sexually transmitted skin diseases. Eosinophilic folliculitis was observed in 3 AIDS patients. The incidence of folliculitis, common warts, seborrheic dermatitis, generalized eczema, oral candidiasis and herpes zoster was higher in HIV-positive than in HIV-negative hemophiliacs (p < 0.05). Although anti-HCV antibody was positive in all HIV-positive hemophiliacs, HCV-related dermatoses such as lichen planus and porphyria cutanea tarda were not observed.
Although Kaposi's sarcoma and sexually transmitted skin diseases such as molluscum contagiosum, condyloma, and scabies are frequently associated with HIV, they were not found in the HIV-positive hemophiliacs in our study. HIV infection-related mucocutaneous manifestations are influenced not only by the presence of HIV but also by other factors such as the mode of transmission and sexual habit.
尽管通过性传播或静脉注射吸毒感染艾滋病毒的患者有各种皮肤黏膜表现的报道，但很少有人描述丙型肝炎病毒（HCV）合并感染的艾滋病毒阳性血友病患者皮肤疾病的患病率和特征。
本研究的目的是阐明艾滋病毒阳性血友病患者皮肤疾病的特征，并确定与其他艾滋病毒阳性群体相比的差异。
1997年7月至1998年7月，对110名日本血友病患者（53名艾滋病毒阳性血友病患者，包括24名艾滋病患者和57名艾滋病毒阴性血友病患者）的皮肤黏膜表现患病率进行了前瞻性研究。
所有血友病患者均未发生卡波西肉瘤或性传播皮肤病。3名艾滋病患者观察到嗜酸性毛囊炎。艾滋病毒阳性血友病患者的毛囊炎、寻常疣、脂溢性皮炎、全身性湿疹、口腔念珠菌病和带状疱疹的发病率高于艾滋病毒阴性血友病患者（p<0.05）。尽管所有艾滋病毒阳性血友病患者的抗HCV抗体均为阳性，但未观察到扁平苔藓和迟发性皮肤卟啉症等丙型肝炎病毒相关皮肤病。
尽管卡波西肉瘤和传染性软疣、尖锐湿疣和疥疮等性传播皮肤病常与艾滋病毒相关，但在我们的研究中，艾滋病毒阳性血友病患者中未发现这些疾病。艾滋病毒感染相关的皮肤黏膜表现不仅受艾滋病毒存在的影响，还受其他因素如传播方式和性习惯的影响。
