Montgomery S M, Ehlin A G C, Sparén P, Björkstén B, Ekbom A
Enheten för klinisk epidemiologi, Institutionen för medicin vid Karolinska sjukhuset, Karolinska Institutet, Stockholm, Sweden.
Br J Cancer. 2002 Oct 21;87(9):989-93. doi: 10.1038/sj.bjc.6600585.
Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting increased susceptibility to HPV infection and cervical cancer. 'Cervical cancer' was self-reported during an interview by 87 of 7594 women members of two longitudinal British birth cohorts. The accuracy of the diagnoses is limited by lack of confirmation using medical records. Odds ratios are adjusted for common warts and eczema in childhood; and cigarette smoking, number of cohabiting partners and social class in early adult life. The odds ratios of warts and eczema with cervical cancer are 2.50 (95% confidence interval 1.14-5.47) and 3.27 (1.95-5.49), respectively. The association of eczema with cervical cancer is independent of hay fever as a marker of atopy, suggesting the importance of non-atopic eczema. Both heavier smoking compared with non-smoking and four or more cohabiting partners compared with one/none have odds ratios for cervical cancer of 8.26 (4.25-15.10) and 4.89 (1.39-17.18), respectively. Common warts in childhood may indicate cervical cancer susceptibility; this and the relationship with eczema deserves investigation.
寻常疣可能预示着患宫颈癌的易感性，因为二者均由人乳头瘤病毒（HPV）引起。研究人员还对湿疹进行了调查，因为特应性湿疹与疣呈负相关，但非特应性湿疹可能与宿主防御功能受损有关，正如在艾滋病患者身上观察到的那样，这表明对HPV感染和宫颈癌的易感性增加。在对英国两个纵向出生队列的7594名女性成员进行访谈时，有87人自述患有“宫颈癌”。由于缺乏病历记录的证实，诊断的准确性受到限制。对儿童时期的寻常疣和湿疹以及成年早期的吸烟情况、同居伴侣数量和社会阶层进行了比值比调整。患疣和湿疹与宫颈癌的比值比分别为2.50（95%置信区间1.14 - 5.47）和3.27（1.95 - 5.49）。湿疹与宫颈癌的关联独立于作为特应性标志物的花粉热，这表明非特应性湿疹的重要性。与不吸烟者相比，吸烟量较大者患宫颈癌的比值比为8.26（4.25 - 15.10）；与有一个/没有同居伴侣者相比，有四个或更多同居伴侣者患宫颈癌的比值比为4.89（1.39 - 17.18）。儿童时期的寻常疣可能预示着患宫颈癌的易感性；这一点以及它与湿疹的关系值得研究。
