Pedersen S, Saeed I
Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Ridebanevej 3, DK-1870 Frederiksberg C, Copenhagen, Denmark.
Parasite. 2000 Dec;7(4):275-81. doi: 10.1051/parasite/2000074275.
The objective of the study was to follow the course of Trichuris suis infection in pigs given infective eggs at low (400 eggs), medium (4,000 eggs) and high inoculation dose (40,000 eggs), respectively. Interestingly, despite a 100-fold difference in dose level no significant difference was found in either blood parameters, total faecal egg excretion, fecundity or worm burdens at necropsy 12 weeks post inoculation. The highest and lowest median faecal egg output was found in the medium and high dose group, respectively. With increasing dose level, worm size, establishment and prevalence of T. suis positive pigs decreased while worms were dislocated aborally. In addition there was a highly significant correlation between female worm burden and faecal egg excretion.
该研究的目的是分别追踪给予低剂量（400个虫卵）、中等剂量（4000个虫卵）和高接种剂量（40000个虫卵）感染性虫卵的猪体内猪鞭虫感染的进程。有趣的是，尽管剂量水平相差100倍，但在接种后12周尸检时，血液参数、粪便总虫卵排泄量、繁殖力或虫负荷方面均未发现显著差异。粪便虫卵输出中位数最高和最低的分别是中等剂量组和高剂量组。随着剂量水平的增加，猪鞭虫的大小、定植率和猪鞭虫阳性猪的患病率降低，同时虫体向口外移位。此外，雌虫负荷与粪便虫卵排泄之间存在高度显著的相关性。
